"Our
study demonstrates that a history of smoking increases a woman’s
risk for developing breast cancer.The difference between this study and many other previous
studies is our definition of smoking. Most previous
studies have assessed smoking status only at the time of
breast cancer diagnosis. As a result, former smokers may
have been misclassified as never smokers and cigarette
exposure underestimated. Our study assessed any history
of smoking prior to or at the time of the breast cancer diagnosis
allowing us to estimate lifetime cigarette exposure. It has been
theorized that smoking affects breast cancer development via the
estrogen metabolism cycle.The
findings from our study provide new evidence that avoidance of
smoking or stopping smoking as soon as possible may reduce
breast cancer risk. All women who smoke should be advised to stop
smoking and provided behavioral and pharmacologic
treatment in accord with clinical practice guidelines"
(Comment
on: Croghan
IT et al.: "The role of smoking in breast cancer development:
an analysis of a Mayo Clinic cohort", Breast
J. 2009 Sep-Oct;15(5):489-95)
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