Gian Paolo Andreoletti, MD, Editor-in-Chief  -  paolo.andreoletti@senology.it

Best Studies of the Month

• de Kruijf EM et al.: "Tumor-stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients", Breast Cancer Res Treat. 2010 Apr 2. [Epub ahead of print]
• Vogel VG et al.: "Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing Breast Cancer", Cancer Prev Res (Phila Pa). 2010 Apr 19. [Epub ahead of print]

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New Evidences

• Multivitamins and breast cancer: "Multivitamin use is associated with an increased risk of breast cancer"  (Larsson SC et al.: "Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women", Am J Clin Nutr. 2010 May:91(5):1268-72)

Literature Selection

• Stevens VL et al.: "Folate and other one-carbon metabolism-related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort", Am J Clin Nutr. 2010 Apr 21. [Epub ahead of print]
• Henderson TO et al.: "Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer", Ann Intern Med. 2010 Apr 6;152(7):444-55; W144-54
• Healy LA et al.: "Metabolic Syndrome, Central Obesity and Insulin Resistance are Associated with Adverse Pathological Features in Postmenopausal Breast Cancer", Clin Oncol (R Coll Radiol). 2010 May:22(4):281-88
• Scomersi S et al.: "Role of magnetic resonance imaging in managing selected women with newly diagnosed breast cancer", Breast. 2010 Apr;19(2):115-9
• Knauer M et al.: "The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer", Breast Cancer Res Treat. 2010 Apr;120(3):655-61
• Degnim AC et al.: "Axillary Recurrence in Breast Cancer Patients with Isolated Tumor Cells in the Sentinel Lymph Node [AJCC N0(i+)].", Ann Surg Oncol. 2010 Apr 14. [Epub ahead of print]
• Pierce LJ et al.: "Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy", Breast Cancer Res Treat. 2010 Apr 22. [Epub ahead of print]
• Palta M et al.: "Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy", Cancer. 2010 Apr:116(3):1872-78
• Kilbreath SL et al.: "Effect of air travel on lymphedema risk in women with history of breast cancer", Breast Cancer Res Treat. 2010 Apr;120(3):649-54

Controversies

• Don't you agree on the conclusions of a clinical study? Please send us a comment and we will publish it

Comment

• Optimal management of breast cancer patients with sentinel lymph node micrometastases" - Sonia Pernas, Medical Oncology Department, Institut Català d'Oncologia, L'Hospitalet, Barcelona, Spain
   
  "Optimal management of breast cancer (BC) patients with sentinel lymph node (SLN) micrometastases remains unclear. Results from randomized trials would be ideal, but most of them closed early because of poor enrollment. With a median follow-up of 60 months, the present prospective study provides evidence that locoregional recurrence or distant disease in BC patients with SLN micrometastases in whom ALND was omitted is very low. Therefore, it supports the theory that further axillary treatment may be avoided in these patients, providing that adjuvant systemic treatment is administered"  
  (Comment on: Pernas S et al.: "Avoiding axillary treatment in sentinel lymph node micrometastases of breast cancer: a prospective analysis of axillary or distant recurrence", Ann Surg Oncol. 2010 Mar;17(3):772-7)

Press Releases

• "Breast cancer patients with BRCA gene mutations are four times more likely to get cancer in opposite breast" - Fred Hutchinson Cancer Research Center, Seattle, WA, USA  - www.fhcrc.org

Calendar of Events

• 2nd Breast Cancer Conference - IMPAKT - of the European Society for Medical Oncology (ESMO), 6-8 May, 2010, Brussels, Belgium
• Breast Cancer Research 2010 Conference, 10 May, 2010, London, UK
• First Joint Summer School on Breast Cancer, University of Insubria - Memorial Sloan-Kettering Cancer Center, June 10-11, 2010, Varese, Italy
• 12th Milan Breast Cancer Conference, June 16-18, 2010, Milan, Italy

Best Studies of the Month

• Fernandes AT et al.: "Elective nodal irradiation (ENI) vs. involved field radiotherapy (IFRT) for locally advanced non-small cell lung cancer (NSCLC): A comparative analysis of toxicities and clinical outcomes", Radiother Oncol. 2010 May:95(2):176-84 
• Andriole GL et al.: "Effect of dutasteride on the risk of prostate cancer", N Engl J Med. 2010 Apr 1;362(13):1192-202

Suggest a study

New Evidences

• Chronic hepatitis C infection and renal cell carcinoma. "Chronic HCV infection confers a risk for the development of renal cell carcinoma"  (Gordon SC et al.: "Risk for Renal Cell Carcinoma in Chronic Hepatitis C Infection", Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1066-73)

Literature Selection

• Chen AM et al.: "Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome", Int J Radiat Oncol Biol Phys. 2010 Apr 14. [Epub ahead of print]
• Croswell JM et al.: "Cumulative incidence of false-positive test results in lung cancer screening: a randomized trial", Ann Intern Med. 2010 Apr 20;152(8):505-12, W176-80
• Boffetta P et al.: "Fruit and Vegetable Intake and Overall Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC", J Natl Cancer Inst. 2010 Apr 6. [Epub ahead of print]
• Kim S et al.: "Intake of Polyunsaturated Fatty Acids and Distal Large Bowel Cancer Risk in Whites and African Americans", Am J Epidemiol. 2010 Apr 14. [Epub ahead of print]
• Wang J et al.: "Standard chemotherapy is superior to high-dose chemotherapy with autologous stem cell transplantation on overall survival as the first-line therapy for patients with aggressive non-Hodgkin lymphoma: a meta-analysis", Med Oncol. 2010 Apr 6. [Epub ahead of print]
• Puumala SE et al.: "Infant leukemia and parental infertility or its treatment: a Children's Oncology Group report", Hum Reprod. 2010 Apr 10. [Epub ahead of print]
• Gutt R et al.: "Statin Use and Risk of Prostate Cancer Recurrence in Men Treated With Radiation Therapy", J Clin Oncol. 2010 Apr 26. [Epub ahead of print]
• Vassil AD et al.: "Five Year Biochemical Recurrence Free Survival for Intermediate Risk Prostate Cancer After Radical Prostatectomy, External Beam Radiation Therapy or Permanent Seed Implantation", Urology. 2010 Apr 6. [Epub ahead of print]
• Richardson PG et al.: "Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma", Blood. 2010 Apr 12. [Epub ahead of print