"It
is important to realize that this is an observational study, and
in such a study we cannot prove that aspirin causes
improved survival. It
is also important to understand that aspirin intake can have
detrimental side effects, such as gastrointestinal bleeding.
To prove that aspirin can improve survival in women with breast
cancer and to ultimately change clinical practice would require
a clinical trial.
However, women with breast cancer who are already advised
by their doctors to take aspirin for another reason (for
instance, heart disease prevention) might take comfort that the
aspirin might also be preventing recurrence of their breast
cancer"
(Comment
on: Holmes
MD et al.: "Aspirin
Intake and Survival After Breast Cancer", J Clin Oncol.
2010 Feb 16. [Epub ahead of print])
"Women
with invasive lobular carcinoma of the breast are at risk for
incomplete tumor excision after breast conserving therapy.
Consequently, the rate of re-excisions in these women is
unacceptably high, ranging from 27 to 67%.
Breast MRI is much better in showing the complete extent of the
tumor and hence facilitates lesion evaluation. Performing
preoperative breast MRI in all women with ILC can reduce the
need for re-excision from 27% to 9%. This can be achieved
without increasing the rate of final mastectomies, so breast MRI
stratifies patients directly to the correct therapy. Moreover
MRI does not need to increase total treatment time. However,
experience in breast MRI for both radiologists and surgeons is
essential"
(Comment
on: Mann
RM et al.: "The impact of preoperative breast MRI on the
re-excision rate in invasive lobular carcinoma of the breast",
Breast
Cancer Res Treat. 2010 Jan;119(2):415-22)
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