"A
metanalysis of 22 studies of MRI screening of the contralateral
breast to newly diagnosed invasive breast cancer showed that 131
contralateral cancers were detected only by MRI among 3253
contralateral breasts (4.1%). Suspicious findings at MRI were
9.3%, with a positive
predictive value of 47.9%. 35.1% of cancers were ductal carcinoma in situ and
64.9% were invasive (mean size
9.3 mm
, most T1 and node negative). Many of these women underwent
contralateral mastectomy. MRI is poorly specific and stage at
diagnosis suggest the risk of overdiagnosis and overtreatment.
Women should be informed of the uncertain benefit and potential
harm, including additional investigations and surgery. There is
no strict indication to systematic MRI screening of the
contralateral breast to primary breast cancer" (Comment
on: Brennan
ME et al.: "Magnetic Resonance Imaging Screening of the
Contralateral Breast in Women With Newly Diagnosed Breast
Cancer:
Systematic Review and Meta-Analysis of Incremental Cancer
Detection and Impact on Surgical Management", J
Clin Oncol. 2009 Nov
20;27(33):5640-9)
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