New Evidences

• Folic acid plus vitamin B12 supplements and cancer:  "Trteatment with folic acid  plus vitamin B12  was associated with increased cancer outcomes" - (Ebbing M et al.: "Cancer Incidence and Mortality After Treatment With Folic Acid and Vitamin B12", JAMA. 2009 Nov 18: 302(19): 2119-26)

Comment

• "Magnetic resonance imaging in patients with a raised PSA and a negative biopsy" - Nathan Lawrentschuk and Neil Fleshner,  Department of Urology and Joint, University Health Network, University of Toronto, Toronto, ON, Canada 
   
  "Our study of the results of MRI in patients either on active surveillance or having prior negative biopsies and an elevated PSA  is important. We believe we have identified aggressive prostate cancers among such men whom represent a sub-group of anterior tumours that easily fit a syndrome when combined with data from other series: PEATS: Prostatic Evasive Anterior Tumours. This warrants further study as these evasive tumours are anteriorly located  and detectable via MRI when standard biopsy techniques have failed. When discrepancy between PSA, PSA dynamics and either a negative biopsy or low volume prostate cancer managed by active surveillance: think of anterior tumours and think of MRI. These tumours are actually fairly aggressive and physicians should be aware of their behaviour. Further research is encouraged to better delineate the prevalence of this condition and how to better detect it earlier in disease ontogeny"
  (Comment on:  Lawrentschuk N et al.: "'Prostatic evasive anterior tumours': the role of magnetic resonance imaging", BJU Int. 2009 Oct 8. [Epub ahead of print])

Press Releases

• "First Cervical Cancer Screening Delayed Until Age 21- Less Frequent Pap Tests Recommended" - American College of Obstetricians and Gynecologists - ACOG - www.acog.org
• "M. D. Anderson Study of Concurrent Radiotherapy, Chemotherapy Shop Promise in Small Cell Lung Cancer" - The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA - www.mdanderson.org
• "First report of using radiolabeled antibodies and stem cell transplantation to successfully treat advanced leukemia" - Fred Hutchinson Cancer Research Center, Seattle, WA, USA  - www.fhcrc.org

Clinical Guidelines

• "NCCN Updates Colorectal Screening Guidelines to Include Additional Primary Screening Modality" - The National Comprehensive Cancer Network, USA - www.nccn.org 
• "NCCN Guidelines for Kidney Cancer Updated to Include Pazopanib for Advanced Disease" - The National Comprehensive Cancer Network, USA - www.nccn.org
• "Topotecan for the treatment of recurrent carcinoma of the cervix" - NICE - National Institute For Clinical Excellence, London, UK - www.nice.org.uk

Literature Selection

• Kenter GG et al.: "Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia", N Engl J Med. 2009 Nov 5;361(19):1838-47
• Mc Tiernan A et al.: "Conjugated Equine Estrogen Influence on Mammographic Density in Postmenopausal Women in a Substudy of the Women's Health Initiative Randomized Trial", J Clin Oncol. 2009 Nov 9. [Epub ahead of print]
• Menes TS et al.: "Rates of atypical ductal hyperplasia have declined with less use of postmenopausal hormone treatment: findings from the Breast Cancer Surveillance Consortium",Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2822-8
• Wu MF et al.: "The efficacy of sertraline for controlling hot flashes in women with or at high risk of developing breast cancer", Breast Cancer Res Treat. 2009 Nov;118(2):369-75