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  • "Combined influence of diet and physical activity on breast cancer survival"  - John Pierce, Cancer Prevention and Control Program, Moores University of California, San Diego Cancer Center, La Jolla, CA, USA

    "WHEL study investigators reported the health outcomes for the 1490 women diagnosed and treated for early-stage breast cancer  in the comparison group of their study.  The study randomized women to a normal "5-a-day" dietary pattern (the comparison group) or to an intensive plant-based dietary pattern (the intervention group). After more  6-11 years of follow-up, the investigators identified a group of women who had almost half the mortality of the other participants.  These were women who, at baseline, consumed more than 5 servings of fruits and vegetables and were physically active for at least 30 min a day, 6 days a week.  Neither physical activity alone or a healthy dietary pattern alone was associated with the survival advantage. Obesity is a known risk factor for poorer survival following breast cancer diagnosis.  One important finding is that women with a BMI over 30 who were both physically active and ate a healthy dietary pattern did not have the increased risk of death normally associated with obesity.    However, only 16% of obese women followed these two healthy lifestyles compared to 30% of non-obese women.   The importance of physical activity and healthy eating for obese women needs to be explored in a randomized trial".
    (Comment on paper:
    Pierce JP et al.: "Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity", J Clin Oncol. 2007; 25(17):2345-51)

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"Prophylactic cranial irradiation (PCI) is part of standard of care in patients with limited SCLC who have reached a complete remission after chemotherapy. The presumption has been that PCI would not be of benefit for patients with extensive SCLC, due to their short life expectancy. However, this randomized, controlled trial shows that in patients with extensive disease SCLC, PCI leads to a significant reduction in the risk of symptomatic brain metastases without compromising quality of life. In addition, PCI was associated with a doubling in 1-year survival. Prophylactic cranial irradiation should now be considered as standard of care for patients with extensive SCLC who respond to chemotherapy
(Comment on paper: Slotman B et al.: 
"Prophylactic cranial irradiation in extensive small-cell lung cancer". N Engl J Med. 2007 Aug 16;357(7):664-72)

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