Gian Paolo Andreoletti, MD, Editor-in-Chief  -  paolo.andreoletti@senology.it

Best Study of the Month

• Heng B et al.: "Human papilloma virus is associated with breast cancer", Br J Cancer. 2009 Sep 1. [Epub ahead of print]

Vote for your favourite study

Literature Selection

• Dragu A et al.: "Intrapulmonary and cutaneous siliconomas after silent silicone breast implant failure", Breast J. 2009 Sep-Oct;15(5):496-9
• Petit JY et al.: "Nipple sparing mastectomy with nipple areola intraoperative radiotherapy: one thousand and one cases of a five years experience at the European institute of oncology of Milan (EIO)", Breast Cancer Res Treat. 2009 Sep;117(2):333-8
• Cardoso F et al.: "International Guidelines for Management of Metastatic Breast Cancer: Combination vs Sequential Single-Agent Chemotherapy", J Natl Cancer Inst. 2009 Aug 5. [Epub ahead of print]
• Mouridsen H et al.: "Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer", N Engl J Med. 2009 Aug 20;361(8):766-76
• Vicus D et al.: "Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers", Gynecol Oncol. 2009 Oct;115(1):135-7
• Alkner S et al.: "Tamoxifen reduces the risk of contralateral breast cancer in premenopausal women: Results from a controlled randomised trial", Eur J Cancer. 2009 Sep;45(14):2496-502
• Smith BD et al.: "Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO)", Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):987-1001
• Jones HA et al.: "Impact of Pathological Characteristics on Local Relapse After Breast-Conserving Therapy: A Subgroup Analysis of the EORTC Boost Versus No Boost Trial", J Clin Oncol. 2009 Aug 31. [Epub ahead of print]
• Halaska MJ et al.: "Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study", Breast J. 2009 Sep-Oct;15(5):461-7
• de Boer M et al.: "Micrometastases or isolated tumor cells and the outcome of breast cancer", N Engl J Med. 2009 Aug 13;361(7):653-63
• Hansen NM et al.: "Impact of Micrometastases in the Sentinel Node of Patients With Invasive Breast Cancer", J Clin Oncol. 2009 Aug 31. [Epub ahead of print]
• Simmons C et al.: "Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?", Ann Oncol. 2009 Sep;20(9):1499-504
• Schmitz KH et al.: "Weight lifting in women with breast-cancer-related lymphedema", N Engl J Med. 2009 Aug 13;361(7):664-73
• Chiarelli AM et al.: "The Contribution of Clinical Breast Examination to the Accuracy of Breast Screening", J Natl Cancer Inst. 2009 Aug 31. [Epub ahead of print]

Comment

• "Oligometastatic disease is potentially curable with multimodality therapy incorporating stereotactic body radiation therapy" - Mike Milano,  Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
   
  "Oligometastases describes a clinical scenario in which a patient has metastases limited in number and extent. Our study describes the outcome of 40 patients with oligometastatic breast cancer, with 5 or fewer radiographically apparent metastatic lesions, treated with curative-intent stereotactic body radiation therapy (SBRT).  Patients with metastases to more than one organ were not excluded.  The actuarial 4-year overall survival was 59%, progression-free survival was 38% and lesion local control (freedom from radiographic growth) was 89%.  Patients with bone-only metastases fared better with respect to survival and disease control.  Bulkier lesions exhibited poorer local control.  The survival and progression free survival numbers are promising.  Breast cancer can have a prolonged disease course, and thus longer follow-up is needed to confirm the hypothesis that oligometastatic disease is potentially curable with multimodality therapy incorporating SBRT"
  (Comment on: Milano MT et al.: "Oligometastatic breast cancer treated with curative-intent stereotactic body radiation therapy", Breast Cancer Res Treat. 2009;115(3):601-8)

Press Releases

• "Long-term tamoxifen use increases the risk of an aggressive, difficult to treat type of second breast cancer" - Fred Hutchinson Cancer Research Center, Seattle, WA, USA  - www.fhcrc.org
• "Study finds obesity, alcohol consumption and smoking increase the risk of developing a second breast cancer" - Fred Hutchinson Cancer Research Center, Seattle, WA, USA  - www.fhcrc.org  

Calendar of Events

• The fascination of art photography of the breast - Quell'instabile oggetto del desiderio,  23 September - 25 October 2009, Padova, Italy
• Australasian Society for Breast Disease Seventh Scientific Meeting, 1-3 October 2009, Gold Coast, Queensland, Australia
• Eighth Annual Controversies in Breast Cancer: Adjuvant and Neoadjuvant Therapy , 16-18 October, 2009, New York, NY, USA
• Meet the Professor. 5th Advanced Course on Breast Cancer, November 4-5-6, 2009,  Modena, Italy

Best Study of the Month

• Prasad GA et al.: "Endoscopic and Surgical Treatment of Mucosal (T1a) Esophageal Adenocarcinoma in Barrett's Esophagus", Gastroenterology. 2009 Sep;137(3):815-23

Vote for your favourite study

Literature Selection

• Van Gossum A et al.: "Capsule endoscopy versus colonoscopy for the detection of polyps and cancer", N Engl J Med. 2009 Jul 16;361(3):264-70.
• Morch LS et al.: "Hormone therapy and ovarian cancer", JAMA. 2009 Jul 15;302(3):298-305
• Smith MR et al.: "Denosumab in men receiving androgen-deprivation therapy for prostate cancer", N Engl J Med. 2009 Aug 20;361(8):745-55
• Nanda A et al.: "Hormonal therapy use for prostate cancer and mortality in men with coronary artery disease-induced congestive heart failure or myocardial infarction", JAMA. 2009 Aug 26;302(8):866-73
• Mandalà M et al.: "Clinical and histopathological risk factors to predict sentinel lymph node positivity, disease-free and overall survival in clinical stages I-II AJCC skin melanoma: outcome analysis from a single-institution prospectively collected database", Eur J Cancer. 2009 Sep;45(14):2537-45
• Rosel R et al.: "Screening for epidermal growth factor receptor mutations in lung cancer.", N Engl J Med. 2009 Sep 3;361(10):958-67