Gian Paolo Andreoletti, MD, Editor-in-Chief  -  paolo.andreoletti@senology.it

Literature Selection

• Ménard S et al.: "Biology, prognosis and response to therapy of breast carcinomas according to HER2 score", Ann Oncol. 2008 Oct;19(10):1706-12
• Fabi A et al.: "Do HER-2 positive metastatic breast cancer patients benefit from the use of trastuzumab beyond disease progression? A mono-institutional experience and systematic review of observational studies", Breast. 2008 Oct;17(5):499-505
• Sharma R et al.: "LHRH agonists for adjuvant therapy of early breast cancer in premenopausal women", Cochrane Database Syst Rev. 2008 Oct 8;(4):CD004562
• Gilbert FJ et al.: "Single Reading with Computer-Aided Detection for Screening Mammography", N Engl J Med. 2008 Oct 1. [Epub ahead of print]
• Chen SL et al.: "The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence", Am J Surg. 2008 Oct;196(4):495-9
• Jhavery JD et al.: "Clinical Outcomes of Postmastectomy Radiation Therapy after Immediate Breast Reconstruction", Int J Radiat Oncol Biol Phys. 2008 Nov 1, 859-865
• Hooning MJ et al.: "Roles of Radiotherapy and Chemotherapy in the Development of Contralateral Breast Cancer", J Clin Oncol. 2008 Oct 14. [Epub ahead of print]
• Galimberti V et al.: "Is Electron Beam Intraoperative Radiotherapy (ELIOT) Safe in Pregnant Women with Early Breast Cancer? In Vivo Dosimetry to Assess Fetal Dose", Ann Surg Oncol. 2008 Oct 21. [Epub ahead of print]
• Gold HT et al.: "Correlates and effect of suboptimal radiotherapy in women with ductal carcinoma in situ or early invasive breast cancer", Cancer. 2008 Oct 17. [Epub ahead of print]
• Navari RM et al.: "Treatment of depressive symptoms in patients with early stage breast cancer undergoing adjuvant therapy", Breast Cancer Res Treat. 2008 Nov;112(1):197-201
• Lin NU et al.: "Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases", Cancer. 2008 Oct 2. [Epub ahead of print]
• Phillips KA et al.: "Psychosocial factors and survival of young women with breast cancer: a population-based prospective cohort study", J Clin Oncol. 2008 Oct 1;26(28):4666-71
• Guo J et al.: "Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42", Cancer Res. 2008 Oct 15;68(20):8473-81

Comments

• "Direct MR galactography is a feasible tool to work up nipple discharge" - Siegfried A. Schwab, Department of Radiology, Universität Erlangen-Nürnberg, German
   
  "The feasibility of direct magnetic resonance galactography (dMRG) with intraductal contrast material injection was evaluated. 23 women with pathologic nipple discharge and pathologic conventional galactographic findings underwent physical examination, ultrasonography, and MR imaging before surgery. Besides the standard magnetic resonance mammography protocol additional high 3D-T1 and 3D-T2 MRG sequences were performed before (indirect magnetic resonance galactography, iMRG) and after (dMRG) gadolinium DTPA was injected into the discharging duct. MR findings were analyzed and compared to conventional galactography and histological reports. (....). We oncluded that direct magnetic resonance galactography  is feasible and may serve as an alternative to conventional galactography in the diagnostic work-up of pathologic nipple discharge. Compared to conventional galactography and standard breast MRI sequences, direct magnetic resonance galactography may provide additional diagnostic information"
  (Comment on:  Schwab SA et al.: "Direct MR galactography: feasibility study.", Radiology. 2008 Oct;249(1):54-61)

   

• "Nonsteroidal anti-inflammatory drugs use is associated with reduced risk for breast cancer" - Bahi Takkouche, Department of of Preventive Medicine, University of Santiago de Compostela, Spain
   
  "The conclusions of our study are globally that regular use of any nonsteroidal anti-inflammatory drug (NSAID) is associated with a relative risk reduction for breast cancer of 12 percent  compared with non-users. A separate analysis for aspirin shows a 13 percent relative risk reduction, and an analysis for ibuprofen showed  a 21 percent relative reduction in risk for breast cancer. However, this does not mean  that we recommend the use of NSAIDs as a preventive measure as these  drugs may cause gastrointestinal bleeding"
  (Comment on:  Takkouche B and al.: "Breast Cancer and Use of Nonsteroidal Anti-inflammatory Drugs: A Meta-analysis", J Natl Cancer Inst. 2008 Oct 7. [Epub ahead of print])

Press Releases

• "Tamoxifen Chemoprevention Tied to Early Detection of Breast Cancer - Researchers find drug may play surprising role in diagnosis of ER-negative disease" - The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA - www.mdanderson.org

• "International implementation of breast health guidelines for developing countries published by Cancer" - Fred Hutchinson Cancer Research Center, Seattle, WA, USA  - www.fhcrc.org

Calendar of Events

• State of the Art Multidisciplinary Care of Breast Disease, November 13-15, Mayo Clinic, Ponte Vedra Beach, FL, USA
• First International Inflammatory Breast Cancer Conference, December 5-7, 2008, Houston, TX, USA
• 31st Annual San Antonio Breast Cancer Symposium, December 10-14, 2008, San Antonio, TX, USA

Images

Infiltrating ductal carcinoma

Stefano Ciatto, - CSPO - Istituto Scientifico Prevenzione Oncologica, Florence, Italy

Literature Selection

• Hassan MM et al.: "Association between hepatitis B virus and pancreatic cancer", J Clin Oncol. 2008 Oct 1;26(28):4557-62
• Pettus JA et al.: "Effect of baseline glomerular filtration rate on survival in patients undergoing partial or radical nephrectomy for renal cortical tumors", Mayo Clin Proc. 2008 Oct;83(10):1101-6
• Chao C et al.: "Alcoholic Beverage Intake and Risk of Lung Cancer: The California Men's Health Study", Cancer Epidemiol Biomarkers Prev. 2008 Oct , 17(10):2602-9
• Aberg F et al.: "Risk of malignant neoplasms after liver transplantation: a population-based study", Liver Transpl. 2008 Oct;14(10):1428-36
• Capussotti L et al.: "Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases", Arch Surg. 2008 Oct;143(10):978-82
• Karapetis CS et al.: "K-ras mutations and benefit from cetuximab in advanced colorectal cancer", N Engl J Med. 2008 Oct 23;359(17):1757-65
• Patel AV et al.: "The role of body weight in the relationship between physical activity and endometrial cancer: results from a large cohort of US women", Int J Cancer. 2008 Oct 15;123(8):1877-82