Gian Paolo Andreoletti, MD, Editor-in-Chief  -  paolo.andreoletti@senology.it

Best Study of the Month

• Le Scodan R et al.: "Breast Cancer With Synchronous Metastases: Survival Impact of Exclusive Locoregional Radiotherapy"; J Clin Oncol. 2009 Feb 9. [Epub ahead of print]

Vote for your favourite study

Literature Selection

• Friese CR et al.: "Breast biopsy patterns and outcomes in Surveillance, Epidemiology, and End Results-Medicare data", Cancer. 2009 Feb 15;115(4):716-24
• Britton PD et al.: "Ultrasound guided percutaneous axillary lymph node core biopsy: How often is the sentinel lymph node being biopsied?", Breast. 2009 Feb;18(1):13-16
• Jackman RJ et al.: "False-negative diagnoses at stereotactic vacuum-assisted needle breast biopsy: long-term follow-up of 1,280 lesions and review of the literature", AJR Am J Roentgenol. 2009 Feb;192(2):341-51
• Gentilini O et al.: "Conservative surgery in patients with multifocal/multicentric breast cancer", Breast Cancer Res Treat. 2009 Feb;113(3):577-83
• Gnant M et al.: "Endocrine therapy plus zoledronic acid in premenopausal breast cancer", N Engl J Med. 2009 Feb 12;360(7):679-91
• Hackshaw A et al.: "Long-term Effectiveness of Adjuvant Goserelin in Premenopausal Women With Early Breast Cancer", J Natl Cancer Inst 2009 0: djn498v1-349- www.jnci.oxfordjournals.org
• McKinnon R et al.: "The prone technique for breast irradiation - is it ready for clinical trials?", Breast. 2009 Feb;18(1):30-34

Comment

• "Radiotherapy After Segmental Resection  is Beneficial Even Among Women With Low Risk Breast Cancer" - Kaija Holli, Departments of Oncology and Surgery, Tampere University Hospital, Tampere University Medical School, Tampere, Finland
   
  "We published in the Journal of Clinical Oncology a data of breast cancer patients (n=264) with favorable prognostic features (age over 40 years, tumour size  2 cm or less, node-negative, progesterone receptor positive, grade I or II, low proliferation rate) who were randomized to receive or not to receive radiotherapy (50 Gy ) after segmental resection. After the median follow-up time of 12.1 years 16 (11.6%) and 34 (27.2%) cancers recurred locally in the radiotherapy and the control arm (p=0.0013). Time to local recurrence was longer in the radiotherapy arm (HR 0.36; 96% Cl, 0.20 to 0.65; p=0.00071). No difference was observed in overall survival time, distant disease-free survival or breast cancer-specific survival between the groups. Radiotherapy significantly reduces the frequency of ipsilateral breast recurrences even among women with very favorable prognostic features. The difference was seen both among premenopausal (p=0.009) and postmenopausal women (P=0.012)"
  (Comment on: Holli K et al.: "Radiotherapy After Segmental Resection of Breast Cancer With Favorable Prognostic Features: 12-Year Follow-Up Results of a Randomized Trial", J Clin Oncol. 2008 Dec 29. [Epub ahead of print])

Press Releases

• "M. D. Anderson Study Finds Pregnancy Has No Impact on Breast Cancer Survival, Does Delay Treatment, Diagnosis  - Researchers encourage close evaluation of breast changes during pregnancy without delay" - The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA - www.mdanderson.org

Clinical Guidelines

• "Early and locally advanced breast cancer: diagnosis and treatment" - NICE - National Institute For Clinical Excellence, London, UK - www.nice.org.uk
• "Advanced breast cancer: diagnosis and treatment" - NICE - National Institute For Clinical Excellence, London, UK - www.nice.org.uk
• "NCCN Updates Breast Cancer and Breast Cancer Risk Reduction Guidelines" - The National Comprehensive Cancer Network, USA - www.nccn.org

Images

Breast lymphoma

Stefano Ciatto, - CSPO - Istituto Scientifico Prevenzione Oncologica, Florence, Italy

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Healthcare Companies News

• Herceptin (Trastuzumab) - Roche - (for Italian subscribers)

Calendar of Events

• Miami Breast Cancer Conference, March 4-7, 2009, Orlando, FL, USA
• 11th International Conference on Primary Therapy of Early Breast Cancer, March 11-14, 2009, St. Gallen, Switzerland
• 2nd Annual Africa Breast Cancer Conference, March 17-18, 2009, Cairo, Egypt
• Kyoto Breast Cancer Conference, April 16-18, 2009, Kyoto, Japan
• IMPAKT Breast Cancer Conference, May 7-9, 2009, Brussels, Belgium

Best Study of the Month

• van der Velde NM et al.: "Time to stop ovarian cancer screening in BRCA1/2 mutation carriers?", Int J Cancer. 2009 Feb 15;124(4):919-23

Vote for your favourite study

Literature Selection

• Young AM et al.: "Warfarin thromboprophylaxis in cancer patients with central venous catheters (WARP): an open-label randomised trial", Lancet. 2009 Feb 14;373(9663):567-574
• Jense A et al.: "Use of fertility drugs and risk of ovarian cancer: Danish Population Based Cohort Study", BMJ. 2009 Feb 5;338:b249
• Kumar S et al.: "Radiation-associated endometrial cancer", Obstet Gynecol. 2009 Feb;113(2 Pt 1):319-25
• Tol J et al.: "Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer", N Engl J Med. 2009 Feb 5;360(6):563-72
• Park Y et al.: "Dairy Food, Calcium, and Risk of Cancer in the NIH-AARP Diet and Health Study", Arch Intern Med. 2009 Feb 23;169(4):391-401
• Graser A et al.: "Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population", Gut. 2009 Feb;58(2):241-8
• Cho YK et al.: "Systematic review of randomized trials for hepatocellular carcinoma treated with percutaneous ablation therapies", Hepatology. 2009 Feb;49(2):453-9
• Landgren O et al.: "B-cell clones as early markers for chronic lymphocytic leukemia", N Engl J Med. 2009 Feb 12;360(7):659-67
• Walsh TJ et al.: "Increased risk of testicular germ cell cancer among infertile men", Arch Intern Med. 2009 Feb 23;169(4):351-6