Gian Paolo Andreoletti, MD, Editor-in-Chief  -  paolo.andreoletti@senology.it

Best Study of the Month

• Khan AJ et al.: "Local control, toxicity, and cosmesis in women younger than 50 enrolled onto the American Society of Breast Surgeons MammoSite Radiation Therapy System registry trial", Ann Surg Oncol. 2009 Jun;16(6):1612-8

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Literature Selection

• Kabat GC et al.: "Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study", Int J Cancer. 2009 May 15;124(10):2430-5
• Crew KD et al.: "High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy", J Clin Oncol. 2009 May 1;27(13):215-16
• Mc Tiernan A et al.: "No effect of aspirin on mammographic density in a randomized controlled clinical trial", Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1524-30
• Beatty JD et al.: "Axillary-conserving surgery is facilitated by neoadjuvant chemotherapy of breast cancer", Am J Surg. 2009 May;197(5):637-41
• Mc Cahill LE et al.: "Quality measures for breast cancer surgery: initial validation of feasibility and assessment of variation among surgeons", Arch Surg. 2009 May;144(5):455-62
• Muss HB et al.: "Adjuvant chemotherapy in older women with early-stage breast cancer", N Engl J Med. 2009 May 14;360(20):2055-65
• Srokowski TP et al.: "Impact of diabetes mellitus on complications and outcomes of adjuvant chemotherapy in older patients with breast cancer", J Clin Oncol. 2009 May 1;27(13):2170-6
• Morey MC et al.: "Effects of home-based diet and exercise on functional outcomes among older, overweight long-term cancer survivors: RENEW: a randomized controlled trial.", JAMA. 2009 May 13;301(18):1883-91
• Manos D et al.: "Results of a multi-componential psychosocial intervention programme for women with early-stage breast cancer in Spain: quality of life and mental adjustment", Eur J Cancer Care 2009 May,; 18(3): 295-305

Comment

• "Systemic inflammation may affect breast epithelial cancer"  - James Goedert, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
   
  "The importance of inflammation and immunity on the development of breast cancer is unclear. Breast cancer risk appears to be somewhat lower in women who use nonsteroidal anti-inflammatory drugs (NSAIDs) or who have rheumatoid arthritis (RA). However, breast cancer risk with other systemic autoimmune rheumatic diseases (SARDs) and particularly by estrogen receptor (ER) status is unknown. In 84,778 women in the American population age 67-99 who developed breast cancer and an equal number of women who did not develop breast cancer, we compared the prevalence of RA and other SARDs. The risk of breast cancer, both ER-positive and ER-negative, was significantly reduced 13% among women with RA.  ER-negative, but not ER-positive, breast cancer also was lower among women with systemic lupus erythematosus (SLE). Other SARDs, most of which are treated with NSAIDs, were unrelated to breast cancer risk. This suggests that alterations of immunity with RA, and perhaps with SLE, reduce the risk of breast cancer among older women. However, the reduction in risk is small with RA, so women with SARDs should still adhere to mammographic screening to assure that breast cancers are detected early and treated effectively"
  (Comment on: Gadalla SM et al.: "Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: a population-based case-control study", Br J Cancer. 2009; 100(5):817-21)

Press Releases

• "Genes Found to Play a Role in Breast Cancer's Spread to the Brain" - Memoria Sloan-Kettering Cancer Center, New York, USA - www.mskcc.org  
• "Novel Gene Predicts Local Recurrence in Early-Onset Breast Cancer" - The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA - www.mdanderson.org
• "M. D. Anderson Study Points Toward Relationship Between Cancer Stem Cells and Prognosis in Primary Breast Cancer" - The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA - www.mdanderson.org

Images

Invasive lobular carcinoma

Stefano Ciatto, - CSPO - Istituto Scientifico Prevenzione Oncologica, Florence, Italy

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Calendar of Events

• 11th Milan Breast Cancer Conference, Jun 17-19, 2009, Milan, Italy
• Great Debates and Updates in Breast Cancer, Jun 19-20, 2009, San Francisco, California, USA
• VIII Madrid Breast Cancer Conference, Jun 24-26, 2009, Madrid, Spain

• Eighth International Congress on the Future of Breast Cancer, Jul 22-25, 2009, Wailea, Maui, HI,  USA

• 15th Annual Perspectives in Breast Cancer, Aug 21-22, 2009, New York, NY, USA

Best Study of the Month

• Baek KH et al.: "Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1", Nature. 2009 May 20. [Epub ahead of print]

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Literature Selection

• Bebenek M et al.: "Abdominosacral Amputation of the Rectum for Low Rectal Cancers: Ten Years of Experience", Ann Surg Oncol. 2009 May 19. [Epub ahead of print]
• Heye T et al.: "CT and endoscopic ultrasound in comparison to endoluminal MRI: preliminary results in staging gastric carcinoma", Eur J Radiol. 2009 May;70(2):336-41
• Hekal IA et al.: "The patients less than 50 years: is there a need to lower the PSA cutoff point?", Prostate Cancer Prostatic Dis. 2009 Jun;12(2):148-51
• Aaltomaa SH et al.: "Eight years experience of local prostate cancer treatment with permanent I(125) seed brachytherapy - Morbidity and outcome results", Radiother Oncol. 2009 May; 91(2):213-16
• Pinkawa M et al.: "Health-related quality of life after permanent I-125 brachytherapy and conformal external beam radiotherapy for prostate cancer - a matched-pair comparison",  Radiother Oncol. 2009 May; 91(2):225-31
• van den Bergh RC et al.: "Gleason score 7 screen-detected prostate cancers initially managed expectantly: outcomes in 50 men", BJU Int. 2009 Jun :103(11);1472-77
• Meeks JJ et al.: "Characteristics of prostate cancers detected at prostate specific antigen levels less than 2.5 ng/ml", J Urol. 2009 Jun;181(6):2515-8
• Souhami L et al.: "Impact of the duration of adjuvant hormonal therapy in patients with locally advanced prostate cancer treated with radiotherapy: a secondary analysis of RTOG 85-31", J Clin Oncol. 2009 May 1;27(13):2137-43
• Sande TA et al.: "Long-term follow-up of cancer patients receiving radiotherapy for bone metastases: Results from a randomised multicentre trial", Radiother Oncol. 2009 May; 91(2):261-66