Gian Paolo Andreoletti, MD, Editor-in-Chief  -  paolo.andreoletti@senology.it

Best Study of the Month

• Sullivan PS et al.: "Should histologic type be taken into account when considering neoadjuvant chemotherapy in breast carcinoma?", Breast J. 2009 Mar-Apr;15(2):146-54

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Literature Selection

• Gadalla SM et al.: "Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: a population-based case-control study", Br J Cancer. 2009 Mar 10;100(5):817-21
• Li Y et al.: "Wine, liquor, beer and risk of breast cancer in a large population", Eur J Cancer. 2009, March 6; 45(5): 789-794
• Cummings SR et al.: "Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk", Natl Cancer Inst. 2009 Mar 10. [Epub ahead of print]
• Carkaci S et al.: "Retrospective Study of 18F-FDG PET/CT in the Diagnosis of Inflammatory Breast Cancer: Preliminary Data", J Nucl Med. 2009; 50(2):231-238
• Litton JK et al.: "Perception of screening and risk reduction surgeries in patients tested for a BRCA deleterious mutation", Cancer. 2009 Mar 11. [Epub ahead of print]
• Beadle BM et al.: "The impact of pregnancy on breast cancer outcomes in women </=35 years", Cancer. 2009 Mar 15;115(6):1174-84
• Coombs NJ et al.: "Internal mammary sentinel nodes: Ignore, irradiate or operate?", Eur J Cancer. 2009, March 6; 45(5): 789-794
• Chagpar AB et al.: "Can sentinel node biopsy be avoided in some elderly breast cancer patients?", Ann Surg. 2009 Mar;249(3):455-60
• Patani N et al.: "The clinical significance of sentinel lymph node micrometastasis in breast cancer", Breast Cancer Res Treat. 2009 Apr;114(3):393-402
• Chadha M et al.: "Intraoperative high-dose-rate brachytherapy--a novel technique in the surgical management of axillary recurrence", Breast J. 2009 Mar-Apr;15(2):140-5
• Taylor CW et al.: "Estimating cardiac exposure from breast cancer radiotherapy in clinical practice", Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1061-8

Comment

• "Impact of locoregional treatment on the survival of breast cancer patients with synchronous metastases" - Romuald Le Scodan, Department of Radiation Oncology, Centre René Huguenin, Saint Cloud, France
   
  "We retrospectively studied the impact of locoregional treatment (LRT), consisting mainly of locoregional radiotherapy (LRR) directed to the breast and regional lymphatics, on the survival of breast cancer patients with synchronous metastases. Among 581 eligible patients treated in our institution between 1980 and 2004, 320 received LRT (group A) and 261 received no LRT (group B). With a median follow-up of 39 months, the 3-year OS rates were 43.4% and 26.7% in group A and group B (p=0.00002). The association between LRT and improved survival was particularly marked in women with visceral metastases. LRT was an independent prognostic factor in multivariate analysis (....). Our results confirm the survival advantage conferred by surgery or radiation therapy of the primary tumor in breast cancer patients with synchronous metastases. Well-designed prospective studies, including locoregional radiotherapy as the only locoregional treatment, are needed to re-evaluate treatment of the primary breast tumor in patients with metastases at diagnosis, and to identify those patients who are most likely to benefit"
  (Comment on: Le Scodan R et al.: "Breast Cancer With Synchronous Metastases: Survival Impact of Exclusive Locoregional Radiotherapy"; J Clin Oncol. 2009 Feb 9. [Epub ahead of print])

Press Releases

• "Super Micro-Surgery Offers New Hope for Breast Cancer Patients with Lymphedema. M. D. Anderson Study Finds Women Who Undergo Lymphaticovenular Bypass Experience Reduction of Lymphatic Fluid by Nearly 40 percent" - The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA - www.mdanderson.org
• "Younger breast cancer patients have greater chance of recurrence" - American Society for Radiation Oncology, USA - www.astro.org
• "Chianti or Chardonnay? It Makes No Difference When It Comes To Red Versus White Wine And Breast-Cancer Risk, Large Study Finds" - Fred Hutchinson Cancer Research Center, Seattle, WA, USA  - www.fhcrc.org

Images

Cystosarcoma phylloides

Stefano Ciatto, - CSPO - Istituto Scientifico Prevenzione Oncologica, Florence, Italy

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Calendar of Events

• Kyoto Breast Cancer Conference, April 16-18, 2009, Kyoto, Japan
• 2nd International Breast Cancer Meeting, April, 23-25, Sarajevo, Bosnia and Herzegovina

• Society of Breast Imaging Biennal Meeting, April 25-29,  Colorado Springs, CO, USA

• IMPAKT Breast Cancer Conference, May 7-9, 2009, Brussels, Belgium

Best Study of the Month

• Sebag-Montefiore D et al.: "Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial", Lancet. 2009 Mar 7;373(9666):811-20

Vote for your favourite study

Literature Selection

• Key TJ et al.: "Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)", Am J Clin Nutr. 2009 Mar 11. [Epub ahead of print]
• Shortt CP et al.: "Whole-Body MRI versus PET in assessment of multiple myeloma disease activity", AJR Am J Roentgenol. 2009 Apr;192(4):980-6
• Andriole GL et al.: "Mortality Results from a Randomized Prostate-Cancer Screening Trial", N Engl J Med. 2009 Mar 18. [Epub ahead of print]
• Schroder FH et al.: "Screening and Prostate-Cancer Mortality in a Randomized European Study", N Engl J Med. 2009 Mar 18. [Epub ahead of print]
• Porter CR et al.: "Adjuvant radiotherapy after radical prostatectomy shows no ability to improve rates of overall and cancer-specific survival in a matched case-control study", BJU Int. 2009 Mar;103(5):597-602
• Menon U et al.: "Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS", Lancet Oncol. 2009 Mar 10. [Epub ahead of print]
• Evans MD et al.: "Outcomes of resection and non-resection strategies in management of patients with advanced colorectal cancer", World J Surg Oncol. 2009 Mar 10;7(1):28. [Epub ahead of print]
• Genkinger JM et al.: "Alcohol Intake and Pancreatic Cancer Risk: A Pooled Analysis of Fourteen Cohort Studies", Cancer Epidemiol Biomarkers Prev. 20089 Mar 3 [Epub ahead of print]
• Sarpel U et al.: "Outcome for Patients Treated with Laparoscopic Versus Open Resection of Hepatocellular Carcinoma: Case-Matched Analysis", Ann Surg Oncol. 2009 Mar 4. [Epub ahead of print]
• Gore JL et al.: "Mortality increases when radical cystectomy is delayed more than 12 weeks : results From a Surveillance, Epidemiology, and End Results-Medicare Analysis", Cancer. 2009 Mar 1;115(5):988-996
• Gee JR et al.: "Reduced bladder cancer recurrence rate with cardioprotective aspirin after intravesical bacille Calmette-Guérin", BJU Int. 2009 Mar;103(6):736-9