Gian Paolo Andreoletti, MD, Editor-in-Chief  -  paolo.andreoletti@senology.it

Literature Selection

• Bigenwald RZ et al.: "Is Mammography Adequate for Screening Women with Inherited BRCA Mutations and Low Breast Density?", Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):706-11
• Huo D et al.: "Parity and breastfeeding are protective against breast cancer in Nigerian women", Br J Cancer. 2008 Mar; [Epub ahead of print]
• Perrin MC et al.: "Gestational diabetes and the risk of breast cancer among women in the Jerusalem Perinatal Study", Breast Cancer Res Treat. 2008 Mar;108(1):129-35
• Rock CL et al.: "Reproductive Steroid Hormones and Recurrence-Free Survival in Women with a History of Breast Cancer", Cancer Epidemiol. Biomarkers Prev 2008 Mar 6 [Epub ahead of print]
• Holmberg L et al.: "Increased Risk of Recurrence After Hormone Replacement Therapy in Breast Cancer Survivors", J Natl Cancer Inst. 2008 Mar 25 [Epub ahead of print]
• Nassar A et al.: "Significance of intramammary lymph nodes in the staging of breast cancer: correlation with tumor characteristics and outcome", Breast J. 2008 Mar-Apr;14(2):147-52
• Muss HB et al.: "Efficacy, Toxicity, and Quality of Life in Older Women With Early-Stage Breast Cancer Treated With Letrozole or Placebo After 5 Years of Tamoxifen: NCIC CTG Intergroup Trial MA.17", J Clin Oncol 2008 Mar 10 [Epub ahead of print]
• Goss PE et al.: "Late Extended Adjuvant Treatment With Letrozole Improves Outcome in Women With Early-Stage Breast Cancer Who Complete 5 Years of Tamoxifen", J Clin Oncol 2008 Mar 10 [Epub ahead of print]
• Mamounas EP et al.: "Benefit From Exemestane As Extended Adjuvant Therapy After 5 Years of Adjuvant Tamoxifen: Intention-to-Treat.Analysis of the National Surgical Adjuvant Breast and Bowel Project B-33 Trial", J Clin Oncol 2008 Mar 10 [Epub ahead of print]
• Kyndi M et al.: "Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group", J Clin Oncol. 2008 Mar 20;26(9):1419-26
• Belletti B et al.: "Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding", Clin Cancer Res. 2008 Mar 1;14(5):1325-1332
• Pachmann K et al.: "Monitoring the response of circulating epithelial tumor cells to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapse", J Clin Oncol. 2008 Mar 10;26(8):1208-15

Editorial

• "Women with breast cancer who exercise are more likely to survive longer than women who are less active" - Crystal N. Holick,  Ingenix i3 Drug Safety, Waltham, MA, USA
   
  "Little is known about the influence of modifiable risk factors on the risk of surviving breast cancer.  Women diagnosed with breast cancer are eager for ways in which they can improve both the quality of their lives and their long-term survival.  In the Collaborative Women’s Longevity Study, nearly 4,500 women who had a previous invasive breast cancer diagnosed between 1988 and 2001 (at ages 20-79 years) completed a questionnaire on recent post diagnosis physical activity and other lifestyle factors.  Findings indicate that women with a breast cancer diagnosis who engaged in recreational exercise after their diagnosis had a 35 percent to 49 percent decreased risk of death from this disease.  The five-year survival rate for breast cancer patients who were moderately active was 97 percent.  Overall, results suggest that women with breast cancer who exercise are more likely to survive longer than women who are less active.  The information gained in this study can help inform and direct women towards specific active participation in their long term lifestyle choices"
  (Comment on paper:  Holick CN et al.: "Physical activity and survival after diagnosis of invasive breast cancer", Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):379-86)

Press Releases

• "Cardiac Effects Associated with Breast Cancer Treatment Appear Lower With Dose-Dense Delivery of Conventional Chemotherapy" - Memorial Sloan-Kettering Cancer Center, New York, USA - www.mskcc.org
• "Body Mass Index May Serve As Prognostic Tool for Advanced, Aggressive Breast Cancers" - The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA - www.mdanderson.org
• "Researchers Identify New Genetic Marker for Breast Cancer" -  Memorial Sloan-Kettering Cancer Center, New York, USA - www.mskcc.org
• "Modified Virus Vaccine Shows Promise in Mouse Model of Breast Cancer" -  National Institutes of Health (NIH), U. S. Department of Health and Human Services - www.nih.gov

Healthcare Companies News

• "Clinical Oncology Publishes Findings from First-Ever Initiative on Sustainable Breast Cancer Treatment in the Developing World" - AstraZeneca - www.astrazeneca.com

Calendar of Events

• 6th European Breast Cancer Conference, 15-19 April, 2008, Berlin, Germany
• American Society of Breast Surgeons - 9th Annual Meeting, April 30-May 4, 2008, New York, NY, USA
• American College of Radiology 33rd National Conference on Breast Cancer; May 8-10, 2008, Orlando, FL, USA
• "Basta" anthracyclines in early breast cancer? - 14th May, 2008, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milano, Italy
• Aggiornamenti in Senologia - 16-17 May, 2008, Napoli, Italy
• Improving Clinical Skills in Early Breast Cancer, 23-25 May, 2008, Ljubljana, Slovenia

Literature Selection

• Diehn M et al.: "Identification of noninvasive imaging surrogates for brain tumor gene-expression modules", Proc Natl Acad Sci U S A. 2008 Mar 24; [Epub ahead of print]
• Arienti V et al.: "Complications of laser ablation for hepatocellular carcinoma: a multicenter study", Radiology. 2008 Mar;246(3):947-55
• Karam JA et al.: "Use of preoperative plasma endoglin for prediction of lymph node metastasis in patients with clinically localized prostate cancer", Clin Cancer Res. 2008 Mar 1;14(5):1418-22
• Saltzman BS et al.: "Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors", Am J Epidemiol. 2008 Mar 1;167(5):607-14
• Ronco G et al.: "Results at Recruitment From a Randomized Controlled Trial Comparing Human Papillomavirus Testing Alone With Conventional Cytology as the Primary Cervical Cancer Screening Test", J Natl Cancer Inst. 2008 Mar 25; [Epub ahead of print]
• Brock MV et al.: "DNA methylation markers and early recurrence in stage I lung cancer", N Engl J Med. 2008 Mar 13;358(11):1118-28
• Gillison ML et al.: "Distinct Risk Factor Profiles for Human Papillomavirus Type 16-Positive and Human Papillomavirus Type 16-Negative Head and Neck Cancers", J Natl Cancer Inst. 2008 Mar 11; [Epub ahead of print]
• Law M et al.: "Gliomas: Predicting Time to Progression or Survival with Cerebral Blood Volume Measurements at Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging", Radiology. 2008 Mar 18; [Epub ahead of print]