Recettori per gli androgeni nel tumore al seno
"The androgen receptor is expressed frequently in breast cancer, but its prognostic significance is unclear. To address this issue we performed a systematic review of electronic databases to identify studies published between 1946 and July 2012, that included nineteen studies with a total of 7693 women. 60.5% of breast cancer patients expressed the androgen receptor. Estrogen receptor-positive tumors were more likely to express the androgen receptor. Expression of this receptor were associated with improved overall survival (OS) at both 3 and 5 years. In conclusion the expression of the androgen receptor in women with breast cancer is associated with better overall survival and disease free survival irrespective of coexpression of ER. Ongoing studies are evaluating the role of targetting this receptor in different breast cancer subtypes”.
(Commentary on: Vera-Badillo FE et al.: "Androgen receptor expression and outcomes in early breast cancer: a systematic review and meta-analysis", J Natl Cancer Inst. 2014 Jan 1;106(1):djt319 http://jnci.oxfordjournals.org/content/106/1/djt319.abstract )