Margini chirurgici e carcinoma mammario triplo-negativo
“Rates of local recurrence following breast conserving therapy differ between breast cancer subtypes, with the highest rates seen in triple-negative cancers and therefore it has been postulated that wider negative margins may improve local control within this subtype. We compared 535 triple-negative cancers with negative margins (no ink on tumor) of <2mm and >2mm and found no significant difference in rates of local recurrence at 5 years. This data, taken with reports that show similar rates of local recurrence in triple-negative cancers treated with mastectomy (the largest possible margin) or lumpectomy, suggest that bad biology is unlikely to be overcome with more extensive surgery”.
(Commentary on: Pilewskie M et al.: "Effect of margin width on local recurrence in triple-negative breast cancer patients treated with breast-conserving therapy", Ann Surg Oncol. 2014 Apr;21(4):1209-14 http://link.springer.com/article/10.1245%2Fs10434-013-3416-5 ) http://link.springer.com/article/10.1245%2Fs10434-013-3416-5