25/10/2012

La metformina nel trattamento del carcinoma pancreatico

"Patients with pancreatic cancer often have a high prevalence (80%) of concurrent diabetes or impaired glucose tolerance, which are characterized by peripheral insulin resistance.  Accumulating epidemiological and experimental evidence suggest metformin, the most commonly used antidiabetic drug, as an antitumor agent. In our retrospective study of 302 diabetic patients with pancreatic cancer, we observed that metformin users had 4 months longer overall survival time, 32% reduced risk of death, and about 2-fold higher 2-year survival rate than the nonmetformin group. These observations add supporting evidence for the antitumor activity of metformin. Findings from this retrospective investigation should prompt future research to test the hypothesis that metformin can be used as a supplemental therapy in the treatment of pancreatic cancer."
(Comment on:  Sadeghi N et al.: "Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer", Clin Cancer Res. 2012 Mar 31. [Epub ahead of print])

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