L'antiepilettico fenitoina riduce la crescita cellulare e le metastasi del tumore mammario
The antiepileptic drug phenytoin reduces tumour growth and metastasis in a preclinical model of breast cancer - William J. Brackenbury, Department of Biology, University of York, Heslington, York, UK
We and others have found that voltage-gated sodium channels, normally present in neurons and muscle cells, are up-regulated in metastatic breast cancer cells. Sodium channels appear to regulate the behaviour of these cancer cells, helping them to migrate and invade out of the primary tumour. This suggests that sodium channels might be useful new therapeutic targets for drugs that could slow metastasis. Sodium channels are important drug targets for treating epilepsy. We have found that the antiepileptic drug phenytoin, which is a sodium channel blocker, reduces tumour growth and metastasis in a preclinical model of breast cancer. We found that phenytoin reduces proliferation of cancer cells within the primary tumour. It also reduces local invasion of cancer cells into the surrounding fat and muscle, and reduces the number of cells metastasising to distant sites in the liver, lungs and spleen. This is the first study to show that phenytoin reduces both the growth and spread of breast cancer tumour cells in vivo. The work suggests that re-purposing antiepileptic drugs is worthy of further study as a potentially novel anti-cancer therapy.