"Circadian disruption on breast cancer risk in women" - Sara Wagner Robb, Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA - "In our comprehensive analysis of 28 observational studies, we found that circadian disruption, including shift work, exposure to light at night, and employment as a flight attendant, was associated with an increased risk of breast cancer in women. Findings from this study should prompt future research to confirm the causal relationship between circadian disruption and breast cancer"
"Whole breast proton irradiation in women with breast cancer" - Mirjam Mast, Radiotherapy Centre West, The Hague, The Netherlands - "When using radiotherapy for left-sided breast cancer a breath-hold technique can be used to decrease the dose in the heart. However, due to anatomical variations in some patients, the radiation dose to the heart remains relatively high, even with the use of advanced photon-based techniques. In a radiotherapy planning study, in which 20 left-sided breast cancer patients were included, we noted that intensity modulated proton therapy (IMPT), when compared to intensity modulated radiotherapy (IMRT; i.e. photon therapy), enabled better sparing of the heart, even without using a breath-hold technique"
"The antiepileptic drug phenytoin reduces tumour growth and metastasis in a preclinical model of breast cancer" - William J. Brackenbury, Department of Biology, University of York, Heslington, York, UK - We and others have found that voltage-gated sodium channels, normally present in neurons and muscle cells, are up-regulated in metastatic breast cancer cells. Sodium channels appear to regulate the behaviour of these cancer cells, helping them to migrate and invade out of the primary tumour. Sodium channels are important drug targets for treating epilepsy. We have found that the antiepileptic drug phenytoin, which is a sodium channel blocker, reduces tumour growth and metastasis in a preclinical model of breast cancer"