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Oligometastatic disease is potentially curable with multimodality therapy incorporating stereotactic body radiation therapy Oligometastases describes a clinical scenario in which a patient has metastases limited in number and extent. Our study describes the outcome of 40 patients with oligometastatic breast cancer, with 5 or fewer radiographically apparent metastatic lesions, treated with curative-intent stereotactic body radiation therapy (SBRT). Patients with metastases to more than one organ were not excluded. The actuarial 4-year overall survival was 59%, progression-free survival was 38% and lesion local control (freedom from radiographic growth) was 89%. Patients with bone-only metastases fared better with respect to survival and disease control. Bulkier lesions exhibited poorer local control. The survival and progression free survival numbers are promising. Breast cancer can have a prolonged disease course, and thus longer follow-up is needed to confirm the hypothesis that oligometastatic disease is potentially curable with multimodality therapy incorporating SBRT.
Bibliographic reference:
Mike Milano Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
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