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Expression of Endothelin-1 and prognosis in non-small cell lung cancer
The
upregulation or alteration of the physiological functions of growth
factors may lead to an unbalanced growth of the cell. Endothelin-1 (ET-1)
is an important growth stimulator in various neoplastic diseases and a
large body of studies demonstrated ET-1 overexpression in many
malignancies. In our study we evaluated the expression of ET-1 and its
receptors in a series of 201 non-small cell lung cancer (NSCLC) and
corresponding normal samples. Our data demonstrated that ET-1 mRNA expression was statistically related to reduced overall survival and disease-free interval. This data may have remarkable importance in terms of biological characterization, suggesting that ET-1 may add useful information regarding the clinical evaluation of NSCLC progression, and that it may represent a potential target for an antiangiogenic therapy using selective ET receptor antagonists.
Reference:
Laura
Boldrini
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