"Timing of breast reconstruction and radiotherapy in women with breast cancer", Liesbeth Boersma, Maastricht University Medical Center, Department of Radiation Oncology, Maastricht, The Netherlands: "Effect of timing of breast reconstruction and radiotherapy (RT), with respect to complications and cosmetic outcomes: a) An implant reconstruction prior to postmastectomy RT yields less complications than after RT; b) Timing of RT has no impact on severe complication rate in case of an autologous reconstruction; c) Autologous reconstruction prior to RT yields more fibrosis than reconstruction after RT; d) Attention should be focused on reporting using standardized outcome measures"
"No evidence of lower mortality with bilateral mastectomy for breast cancer" - Scarlett Lin Gomez, Cancer Prevention Institute of California, Greater Bay Area Cancer Registry, Fremont, CA, USA - "Among California women with stages 0-III breast cancer less than 5 cm in size, rates of double mastectomy have increased steadily, from 2% of women receiving double mastectomy in 1998 to more than 12% in 2011. The rate of increase was fastest among women younger than age 40 at diagnosis, among whom more than one-third of women in 2011 had a double mastectomy. We found no evidence of lower mortality in comparison to breast conserving surgery plus radiation, even after accounting for characteristics of the women themselves, their tumor type, and where they were seen".
"Effect of margin width on local recurrence in women with triple-negative breast cancer"- Melissa Pilewskie, Memorial Sloan-Kettering Cancer Center, New York, USA: "Rates of local recurrence following breast conserving therapy differ between breast cancer subtypes, with the highest rates seen in triple-negative cancers and therefore it has been postulated that wider negative margins may improve local control within this subtype. Our data, taken with reports that show similar rates of local recurrence in triple-negative cancers treated with mastectomy or lumpectomy, suggest that bad biology is unlikely to be overcome with more extensive surgery"