"The antiepileptic drug phenytoin reduces tumour growth and metastasis in a preclinical model of breast cancer" - William J. Brackenbury, Department of Biology, University of York, Heslington, York, UK - We and others have found that voltage-gated sodium channels, normally present in neurons and muscle cells, are up-regulated in metastatic breast cancer cells. Sodium channels appear to regulate the behaviour of these cancer cells, helping them to migrate and invade out of the primary tumour. Sodium channels are important drug targets for treating epilepsy. We have found that the antiepileptic drug phenytoin, which is a sodium channel blocker, reduces tumour growth and metastasis in a preclinical model of breast cancer
"Radiotherapy for women with a DCIS" - Fredrik Warnberg, Uppsala University, Uppsala, Sweden. "Today in Sweden, according to our national guidelines we do not give radiotherapy to women with a DCIS, grade 1 or 2, smaller than 15mm. We know that we can reduce the number of local recurrences even in this group but the absolute benefit is very low and we think the disadvantage is larger than the gain"
"Circadian disruption on breast cancer risk in women" - Sara Wagner Robb, Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA - "In our comprehensive analysis of 28 observational studies, we found that circadian disruption, including shift work, exposure to light at night, and employment as a flight attendant, was associated with an increased risk of breast cancer in women. Findings from this study should prompt future research to confirm the causal relationship between circadian disruption and breast cancer"